Azithromycin in the treatment of infection with Neisseria.

Regulation of Capsule in Neisseria Meningitidis Yih-Ling Tzeng 1, Jennifer Thomas 1, David S Stephens 1. In commensal N. meningitidis lacking the cps locus (capsule null locus, cnl), N. gonorrhoeae and N. lactamica, tex and galE are adjacent. The representatives of each serogroup shown are A: Z2491, B: MC58, C: FAM18, Y: GA0929, W: GA1002 and X: M7575. Figure 2. 5 A hypothetical model of.

What is Neisseria gonorrhoeae?. The prevalence of gonorrhea (Neisseria gonorrheae) in the United States and abroad, especially under-developed and developing countries, has decreased in the last two decades.As of recently, though, higher rates of infection have been reported due to the increase of antimicrobial -resistant gonococci (Knapp et al., 1994).

Characterization of the Gene Cassette Required for.

Thirteen Neisseria meningitidis serogroups have been described on the basis of serologic differences of the capsule; of these 13 serogroups, 6 (A, B, C, W, X, Y) cause invasive meningococcal disease. The polysaccharide capsule is a key virulence determinant, and for serogroups A, C, W, and Y, it forms the basis of polysaccharide conjugate vaccines.In this study the addition of casein hydrolysate to standard media was found to promote capsule development in 4 out of 5 freshly isolated gonococcal strains. The capsule was visualized in wet-ink preparations and in the electron microscope by the use of homologous hyperimmune serum. Organisms harvested from transparent agar were not consistently surrounded by a clear area in Indian ink.The family Neisseriaceae is currently the only family within the order Neisseriales, which in addition to the genus Neisseria contains Eikenella, Kingella, and 27 other genera. Multiple-locus instead of single-locus approaches might therefore be more suitable for the resolution of species identification within the genus Neisseria. Neisseria species produce acid from carbohydrates by oxidation.


Neisseria meningitidis and N. gonorrhoeae are exclusive human pathogens.N. meningitidis is a leading cause of sepsis and meningitis, whereas N. gonorrhoeae (gonococcus) traditionally causes gonorrhea, a sexually transmitted infection involving the genitals, rectum, and throat. These species usually occupy distinct niches but may cause reciprocal diseases when N. meningitidis colonizes the.Gonorrhea is a sexually transmitted disease caused by various strains of the gram -negative. The cell wall of Neisseria gonorrhoeae contains lipopolysaccharide, protein, and phospholipid. It lacks a true polysaccharide capsule, but projecting from the cell wall are hairlike extensions called pili. Within these pili is a protease that digest IgA on the surface of the mucus membrane, thus.

We have investigated genetic differences between the closely related pathogenic Neisseria species, Neisseria meningitidis and Neisseria gonorrhoeae, as a novel approach to the elucidation of the genetic basis for their different pathogenicities. N. meningitidis is a major cause of cerebrospinal meningitis, whereas N. gonorrhoeae is the agent of gonorrhoea. The technique of representational.

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Neisseria. 10 species found in humans Gonorrhoeae and meningitides are human pathogens commonly found on mucosal surfaces or oropharynx and nasopharynx. Neisseria gonorrhoeae.

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Electron photomicrographs of Neisseria gonorrhoeae prepared by the electron microscopic India ink technique: a, false capsule on gonococci grown in broth culture-clear area caused by separation of bacterial outer membrane ( x 20,000); b, false capsule on organism with intact cell wall in urethral exudate-clear area caused by sur-rounding membrane of unknown origin (possibly derived from.

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Neisseria gonorrhoeae can be induced to form a large capsule that can be visualized with India ink. Encapsulated gonococci appeared to be resistant to non-antibody-mediated phagocytosis compared with unencapsulated gonococci of the same strain and colony type. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete.

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Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of Gram-negative diplococci bacteria isolated by Albert Neisser in 1879. (3) It causes the sexually transmitted genitourinary infection gonorrhea (4) as well as other forms of gonococcal disease including disseminated gonococcemia, septic arthritis, and gonococcal ophthalmia neonatorum.

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Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative diplococci.N. gonorrhoeae is the causative agent of gonorrhoea and is transmitted via sexual contact.N. meningitidis is transmitted via respiratory droplets leading to colonization of the nasopharynx and can cause meningitis and septicemia. This important reference volume provides research scientists, advanced students.

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Gonorrhea, sexually transmitted disease characterized principally by inflammation of the mucous membranes of the genital tract and urethra. It is caused by the gonococcus, Neisseria gonorrhoeae—a bacterium with a predilection for the type of mucous membranes found in the genitourinary tract and.

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Capsule switching may be an important virulence mechanism of meningococci and other encapsulated bacterial pathogens. As vaccine development progresses and broader immunization with capsular polysaccharide conjugate vaccines becomes a reality, the ability to switch capsular types may have important implications for the impact of these vaccines. The different sialic acid (serogroups B, C, Y.

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The causative agent of gonorrhea, Neisseria gonorrhoeae, was first described by A. Neisser in 1879, in the pustular exudate of a case of gonorrhea. The organism was grown in pure culture in 1885, and its etiological relationship to human disease was later established using human volunteers in order to fulfill the experimental requirements of Koch's postulates. Gonorrheal infection is generally.

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Epidemiology. Except for Neisseria gonorrhoeae, the organisms considered in Table 40-1 are normal inhabitants of the upper respiratory tract of humans. Humans are the only natural host for N. gonorrhoeae, primarily a clinically significant pathogen found in the urogenital tract and never considered normal flora. Asymptomatic carriers of gonorrhea are the primary reservoir for dissemination in.

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